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Analyzing Intracellular Short Linear Motifs of AMIGO and NGL Orthologs

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LIGs are transmembrane proteins, containing a leucine-rich repeat (LRR) and immunoglobulin-like (Ig) domain, important in cell interactions and signaling. There are 36 human LIG proteins, of which the AMIGO and NGL subfamilies have sizable intracellular domains of which minimal functional knowledge has been obtained. Within intracellular regions, short linear motifs (SLiMs) that function as targeting signals, modification sites, and protein binding sites may exist. Identification of motifs conserved across different species provides a phylogenetic approach to aid in discovery of functional SLiMs. In this study, orthologs of AMIGO and NGL human proteins were identified in Mus musculus (mouse), Gallus gallus (chicken), Callorhinchus milii (elephant shark) and used to identify putative SLiMs.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-012617-143641
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  • 2017
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  • 2017-01-26
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