Faculty Advisor

Duffy, Joseph B.

Abstract

LIGs are transmembrane proteins, containing a leucine-rich repeat (LRR) and immunoglobulin-like (Ig) domain, important in cell interactions and signaling. There are 36 human LIG proteins, of which the AMIGO and NGL subfamilies have sizable intracellular domains of which minimal functional knowledge has been obtained. Within intracellular regions, short linear motifs (SLiMs) that function as targeting signals, modification sites, and protein binding sites may exist. Identification of motifs conserved across different species provides a phylogenetic approach to aid in discovery of functional SLiMs. In this study, orthologs of AMIGO and NGL human proteins were identified in Mus musculus (mouse), Gallus gallus (chicken), Callorhinchus milii (elephant shark) and used to identify putative SLiMs.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2017

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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