Faculty Advisor

Duffy, Joseph B.

Abstract

Aberrant signaling by the epidermal growth factor receptor (ErbB) family plays a central role in tumor development and is a target for pharmacological intervention. A major challenge in drug discovery is the evaluation of new compounds at the organismal level. Due to conservation of the ErbB network between Drosophila and humans, flies offer an attractive system for this. I have generated transgenic Drosophila with human ErbB receptors and used them to develop an in vivo assay to screen for therapeutics.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Your accessibility may vary due to other restrictions.

Share

COinS