Faculty Advisor

Duffy, Joseph B.

Abstract

Lipids are known to be important for proper cellular and metabolic functions. Lipid disorders include Tay Sach's, Gaucher's, Neimann-Pick, diabetes, adrenoleukodystrophy (ALD), and macular degeneration. Macular degeneration has been linked to mutations in a lipid elongase, of which 7 exist in humans and 20 in the fruit fly, Drosophila melanogaster. To understand the contributions of elongases to development, I surveyed their function in Drosophila using RNAi. I identified sit still (sit), whose phenotype suggests a model for neurodegenerative diseases like multiple sclerosis.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2009

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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