Faculty Advisor

Adams, David S.

Abstract

Listeria monocytogenes is gram positive bacterium which can cause overt infection in humans through consumption of contaminated food and beverages. Two host genes CD5l and CCR2 play a major role in the innate immune response to such infection. Both CCR2 and CD5l are differentially expressed in mouse strains that differ in their susceptibility to L. monocytogenes infection. Therefore differential expression of these genes could be contributing to susceptibility to infection. The purpose of this project is to determine what regulates these genes at a molecular level through mouse models. A genome wide mapping was performed using 42 N2 backcross mice. A linkage between CD5l and CCR2 expression levels to markers on each chromosome was tested using genetic mapping software (Map Manager).

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2009

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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