Faculty Advisor

Adams, David S.

Abstract

LNFPIII, a schistosome glycan, has been shown to induce an anti-inflammatory response in vivo and in vitro. In this study we demonstrate the effects that LNFPIII has on macrophages using mouse models. When mice are injected with LNFPIII-dex the production of inflammatory cytokine IL-6 is significantly decreased, compared to uninjected and dextran injected mice. We also found that macrophages from LNFPIII injected mice show signs of alternative activation, including the upregulation of Arginase-1. LNFPIII-activated macrophages also express higher levels of the surface markers CD80 and PDL-1. Lastly, LNFPIII- activated macrophages were able to prime T cells in vitro as seen by a decrease in the production of IFN Gamma and IL-13.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2008

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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