Faculty Advisor

Adams, David S.

Faculty Advisor

Heilman, Destin

Abstract

Lymantria dispar (Ld652) cells are normally resistant to infection by vesicular stomatitis virus (VSV), a simple RNA virus. However, when co-infected with vaccinia virus (VACV), a poxvirus used as a vaccine for smallpox, VSV is able to productively infect these cells. Previous work has shown that the sole factor responsible for this rescue of VSV by VACV is a highly conserved poxvirus protein known as A51, but the mechanism of this rescue is not currently understood. The mechanism behind this rescue was investigated using a yeast two-hybrid system to identify potential A51-binding proteins.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2014

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemistry and Biochemistry

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