Sotak, Christopher Howard
Magnetic resonance imaging (MRI) was used for accurate and dynamic monitoring of tissue embedded microthreads; a novel biomaterial utilized to promote cardiac regeneration. An in vitro cardiac modeling system was developed that mimicked the MRI properties of native cardiac tissue by using gelatin of varying concentrations. Microthreads were treated with an iron-based superparamagnetic MRI contrast agent (ferumoxtran), embedded into the cardiac modeling system, and then imaged using MRI. T1- and T2-weighted MR images showed no statistical difference between actual thread location and diameter when compared with the same measurements obtained from optical images of the same cardiac modeling system.
Worcester Polytechnic Institute
Major Qualifying Project
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