Faculty Advisor

Pins, George

Faculty Advisor

Sotak, Christopher Howard

Abstract

Magnetic resonance imaging (MRI) was used for accurate and dynamic monitoring of tissue embedded microthreads; a novel biomaterial utilized to promote cardiac regeneration. An in vitro cardiac modeling system was developed that mimicked the MRI properties of native cardiac tissue by using gelatin of varying concentrations. Microthreads were treated with an iron-based superparamagnetic MRI contrast agent (ferumoxtran), embedded into the cardiac modeling system, and then imaged using MRI. T1- and T2-weighted MR images showed no statistical difference between actual thread location and diameter when compared with the same measurements obtained from optical images of the same cardiac modeling system.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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