Faculty Advisor

Gericke, Arne

Center

Zurich, Switzerland

Abstract

Matrix metalloproteinases (MMPs) are a group of complex enzymes known for their role in ECM turnover and homeostasis. These proteinases additionally participate in many other biological processes, but when deregulated contribute to different pathological processes and diseases such as multiple sclerosis and rheumatoid arthritis. Therefore MMPs require tight regulation of their activity. The focus of this project was to gain an understanding of MMPs and to synthesize different novel inhibitors aimed at MMPs and other biological targets.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2016

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Project Center

Zurich, Switzerland

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