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MdmX Suppresses Chromosome Loss and Multipolar Mitosis in p53-Independent Manner

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Mdm2 and MdmX are homologous proteins that function as oncogenes by negatively regulating the tumor suppressor p53. The overexpression of each has been linked to the tumorigenesis and metastasis of a significant portion of human cancers. Recent studies have shown that MdmX can also function as a tumor suppressor by promoting genome stability in a p53-independent manner. Data has now further identified that the Zinc Finger (ZnF) region of MdmX is the key determinant to this function. This project aimed to generate, validate, and functionally analyze mouse epithelial tumor cell lines suitable for the future identification of MdmX interactive protein partners. Also of interest was to explore whether the role of MdmX in supporting genome stability requires intact Mdm2 function.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-022916-112040
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Year
  • 2016
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Date created
  • 2016-02-29
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Last modified
  • 2023-11-07

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