Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Menopausal women may use hormone replacement therapy (HRT) for symptomatic relief, assuming that herbal HRTs are safe because they are "natural". Promensil is one such supplement. The proliferative effects of its specific components, biochanin A and formononetin were investigated using human ductal carcinoma cells. Results indicate that > 10uM biochanin A inhibits and <10uM biochanin A promotes cell proliferation. Formononetin had no apparent effect. These results indicate that herbal HRTs may not be safe for women with breast cancer.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Share

COinS