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The Effects of Phytoestrogens Found in Promensil on Human Ductal Carcinoma

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Menopausal women may use hormone replacement therapy (HRT) for symptomatic relief, assuming that herbal HRTs are safe because they are "natural". Promensil is one such supplement. The proliferative effects of its specific components, biochanin A and formononetin were investigated using human ductal carcinoma cells. Results indicate that >10uM biochanin A inhibits and <10uM biochanin A promotes cell proliferation. Fromononetin had no apparent effect. These results indicate that herbal HRTs may not be safe for women with breast cancer.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042910-120412
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  • 2010
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  • 2010-04-29
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