Faculty Advisor

Adams, David S.

Faculty Advisor

Ruiz, Carolina

Abstract

Microarray data of 1,056 breast tumors from NCBI's GEO database were collected and analyzed. The goal was to discover microarrays most similar to a potentially novel subtype of breast cancer characterized by low claudin expression. Claudins form tight junctions, which regulate cell-cell movement of solutes and ions; faulty tight junctions have been correlated with cancer metastasis. Results showed little support for a Claudin-Low cluster. Nine clusters were found, when 5-6 were expected. These additional clusters may reveal novel subtypes.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Major

Computer Science

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Computer Science

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