Microarray data of 1,056 breast tumors from NCBI's GEO database were collected and analyzed. The goal was to discover microarrays most similar to a potentially novel subtype of breast cancer characterized by low claudin expression. Claudins form tight junctions, which regulate cell-cell movement of solutes and ions; faulty tight junctions have been correlated with cancer metastasis. Results showed little support for a Claudin-Low cluster. Nine clusters were found, when 5-6 were expected. These additional clusters may reveal novel subtypes.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Liu, Justin
• Davidson, Philip Allen

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042910-150755

Advisor

• Ruiz, Carolina
• Adams, David S.

Year

• 2010

Sponsor

• Karl Simin

Date created

• 2010-04-29

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright