Faculty Advisor

Faber, Brenton

Faculty Advisor

Rao, Reeta Prusty

Abstract

Microbes play a key role in the pathology of inflammatory bowel disease even though the cause remains unknown. Here we report that Caenorhabditis elegans live longer when first exposed to Bacillus subtilis compared to animals exposed to pathogenic fungus Candida albicans alone, suggesting a probiotic effect of B. subtilis biofilm. This result was bolstered by the finding that mutant B. subtilis that are unable to form biofilms are unable to provide protection against C.albicans infection and animals that are unable to mount an immune response are also susceptible to C. albicans despite probiotic treatment.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Interdisciplinary

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Humanities and Arts

Advisor Department

Biology and Biotechnology

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