Rao, Reeta Prusty
Microbes play a key role in the pathology of inflammatory bowel disease even though the cause remains unknown. Here we report that Caenorhabditis elegans live longer when first exposed to Bacillus subtilis compared to animals exposed to pathogenic fungus Candida albicans alone, suggesting a probiotic effect of B. subtilis biofilm. This result was bolstered by the finding that mutant B. subtilis that are unable to form biofilms are unable to provide protection against C.albicans infection and animals that are unable to mount an immune response are also susceptible to C. albicans despite probiotic treatment.
Worcester Polytechnic Institute
Major Qualifying Project
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Humanities and Arts
Biology and Biotechnology