Faculty Advisor

Adams, David S.

Abstract

Activation of the innate immune system is important for normal host responses to infections. Mice lacking MyD88, an adaptor molecule essential for signaling by a family of innate immune receptors, were shown to have impaired long-term antibody responses to systemic infection with polyomavirus (PyV). The goal of this MQP was to examine the role of MyD88 in antibody responses to acute respiratory PyV infection and to viral re-challenges.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2008

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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