Faculty Advisor

Thalladi, Venkat R.

Abstract

Microwave heating is rapid, efficient, selective and volumetric. We explore the application of these unique properties in the dehydration and subsequent polymorph selection of active pharmaceutical ingredients (APIs). Traditional heating methods, such as hot plates, oil baths, and ovens are often lengthy in time and require the application of heat to the entire material. Microwave heating, on the other hand, takes advantage of the affinity and selectivity of the microwaves to the water molecules present in hydrated crystalline structures, therefore allowing for unique dehydration paths. This project explores the outcomes of using microwave heating to dehydrate caffeine -- an API commonly used in the pharmaceutical industry.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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