Faculty Advisor

Heilman, Destin

Faculty Advisor

Manning, Amity L.

Abstract

Acute Myeloid Leukemia (AML) is a cancer of overproliferative blood cells and is the most common type of blood cancer to occur in adults. AML patients are commonly treated with chemotherapeutic approaches. Currently, the identification and development of therapies that specifically or preferentially impact growth of leukemia cells is in high demand. Our studies have focused on exploring the molecular effects of Aurora A inhibition, and investigating cellular biomarkers, in addition to Aurora A levels, that may predict drug sensitivity in AML patients. Our initial correlative studies on AML cell lines, does not show a clear correlation between Aurora A levels and Alisertib sensitivity. Instead, they suggest that an increased centriole number confers resistance of AML cells to Alisertib.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

Share

COinS