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ABI-1 interaction with MIG-10: Protein interaction in neuronal migration in Caenorhabditis elegans

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MIG-10 is a C.elegans protein known to stimulate lamellipodia formation in directed neuronal migration and cause truncation of the excretory canal. MIG-10 was found to physically interact with Ableson Interacting Protein 1 (ABI-1) in vitro, which is being confirmed by Co-IP. The proteins' interaction in vivo was studied using RNAi expression knockdown. MIG-10 mutants showed increased truncation of the excretory canal when fed ABI-1 RNAi. We concluded that MIG-10 and ABI-1 may reside in different pathways, but have overlapping functions.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-043009-121202
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Year
  • 2009
Date created
  • 2009-04-30
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Last modified
  • 2021-02-02

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