Faculty Advisor

Ryder, Elizabeth F

Abstract

MIG-10 is a C.elegans protein known to stimulate lamellipodia formation in directed neuronal migration and cause truncation of the excretory canal. MIG-10 was found to physically interact with Ableson Interacting Protein 1 (ABI-1) in vitro, which is being confirmed by Co-IP. The proteins' interaction in vivo was studied using RNAi expression knockdown. MIG-10 mutants showed increased truncation of the excretory canal when fed ABI-1 RNAi. We concluded that MIG-10 and ABI-1 may reside in different pathways, but have overlapping functions.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2009

Major

Biology and Biotechnology

Major

Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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