Faculty Advisor

Ryder, Elizabeth F

Abstract

MIG-10 is a protein known to be involved in axon guidance and neuronal migration in early development in C. elegans. In an effort to better understand the protein's function, this project used the yeast two hybrid system to screen a cDNA library (representing the entire C. elegans genome) for proteins with which MIG-10 interacts. The idea is if we can associate it with proteins of known function, we'll have a better idea as to what MIG-10 itself does. Our research revealed that MIG-10 interacts with (among other proteins) ABI-1, which is a component of actin polymerization machinery.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

BIO

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