MIG-10 is involved in the signal transduction of guidance cues during neuronal migration and has shown putative interactions with CSN-5 and ARX-3. CSN-5 is involved in protein degradation; ARX-3 is involved in actin polymerization. To determine whether these interactions are significant in vivo, RNAi was used to silence csn-5 and arx-3. RNAi of csn-5 exhibited truncation of specific neuron migration; meanwhile there is currently ongoing experimentation with arx-3. These results may suggest that CSN-5 regulates the degradation of MIG-10 during development.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• McMasters, Jessica Ann

Contributors

• Flaherty, Erin

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042513-152100

Advisor

• Ryder, Elizabeth F.

Year

• 2013

Date created

• 2013-04-25

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright