Faculty Advisor

Ryder, Elizabeth F.

Abstract

MIG-10 is involved in the signal transduction of guidance cues during neuronal migration and has shown putative interactions with CSN-5 and ARX-3. CSN-5 is involved in protein degradation; ARX-3 is involved in actin polymerization. To determine whether these interactions are significant in vivo, RNAi was used to silence csn-5 and arx-3. RNAi of csn-5 exhibited truncation of specific neuron migration; meanwhile there is currently ongoing experimentation with arx-3. These results may suggest that CSN-5 regulates the degradation of MIG-10 during development.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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