Faculty Advisor

Gibson, Daniel G

Abstract

Most arthropod species use glutamate as their principal excitatory neuromuscular transmitter, but we present evidence that this role is played by acetylcholine in walking legs of the horseshoe crab, Limulus polyphemus. Agonists of cholinergic transmission enhance neuronally evoked contractions, while antagonists inhibit these contractions. Videorecording and electrical recording were both used to gather this data. Considering the lineage of arthropod taxa, cholinergic innervation of arthropod muscle may predate the glutamatergic innervation of crustaceans and insects.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2005

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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