Mouse models are commonly used to investigate bone healing and test new treatments. The objectives of this project were to design a fracture device to create a reproducible transverse fracture in the mouse femur and to establish the limits of achieving transverse fractures. Testing with 26.4 +/- 6.1g wildtype mice (n=120) developed a model equation of mv^2=0.292 to predict a 95% transverse fracture success rate. These results are useful to researchers who are interested in obtaining a higher transverse fracture success rate.
Worcester Polytechnic Institute
Major Qualifying Project
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