Mouse models are commonly used to investigate bone healing and test new treatments. The objectives of this project were to design a fracture device to create a reproducible transverse fracture in the mouse femur and to establish the limits of achieving transverse fractures. Testing with 26.4 +/- 6.1g wildtype mice (n=120) developed a model equation of mv^2=0.292 to predict a 95% transverse fracture success rate. These results are useful to researchers who are interested in obtaining a higher transverse fracture success rate.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Byrne, Melissa A.
• Marturano, Joseph E.
• Cleveland, Benjamin C.

Contributors

• Wixted, John J.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-030207-112622

Advisor

• Billiar, Kristen

Year

• 2007

Sponsor

• University of Massachusetts Memorial Hospital

Date created

• 2007-03-02

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright