Faculty Advisor

Rulfs, Jill

Abstract

Multiple Sclerosis (MS) is the most common cause of neurological disability in young adults. In this study, the animal model of MS, experimental autoimmune encephalomyelitis (EAE) was used in conjunction with tissue harvest techniques, flow cytometry and an ex vivo assay system in order to immunophenotype cellular infiltrate over the course of disease, study microglial activation, evaluate the ability of microglia to stimulate T-cells and to determine the effects of small molecule inhibitors on certain biochemical pathways. This study demonstrates that CNS infiltrate kinetics mirror disease course and suggests that microglia be involved in antigen presentation and effector function during disease course.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2009

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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