Faculty Advisor

Ryder, Elizabeth F.

Abstract

Mutations in genes involved in nervous system development can result in disorders such as Down’s syndrome and autism. MIG-10 is a cytoplasmic adaptor protein in the model system C. elegans that functions in neuronal migration and axon guidance during development. To study possible interactions between MIG-10 and candidate protein CSN-5, co-immunoprecipitation and western blotting were performed. An interaction between MIG-10 and CSN-5 was confirmed, suggesting that CSN-5 is needed to stabilize MIG-10.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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