Faculty Advisor
Ryder, Elizabeth F.
Abstract
Mutations in genes involved in nervous system development can result in disorders such as Down’s syndrome and autism. MIG-10 is a cytoplasmic adaptor protein in the model system C. elegans that functions in neuronal migration and axon guidance during development. To study possible interactions between MIG-10 and candidate protein CSN-5, co-immunoprecipitation and western blotting were performed. An interaction between MIG-10 and CSN-5 was confirmed, suggesting that CSN-5 is needed to stabilize MIG-10.
Publisher
Worcester Polytechnic Institute
Date Accepted
April 2013
Major
Biology and Biotechnology
Project Type
Major Qualifying Project
Copyright Statement
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Accessibility
Unrestricted
Advisor Department
Biology and Biotechnology