Faculty Advisor

Ryder, Elizabeth F.

Abstract

Mutations in mig-10 and unc-53 in C. elegans result in defects in axon guidance and excretory canal outgrowth. To better understand these genes' effects on migration and outgrowth, single and double mutant phenotypes were compared. In mig-10 mutants, excretory canal truncation is first observed during embryogenesis. Rescue experiments show that MIG-10 functions cell autonomously in the excretory cell. Phenotypes of single and double mutants suggest that mig-10 and unc-53 may have varying functions in different cells.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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