Faculty Advisor

Adams, David S.

Abstract

Mutations in stem cell signaling caused by alterations in the Lef1 beta-catenin pathway can lead to the development of sebaceous tumors in humans. A survey of known stem cell markers was conducted on a human sebaceous tumor line and on normal skin using immunoflourescence, PCR and Western Blots to verify the existence of stem cells in sebaceous tumors. The resulting data supports the existence of cancer stem cells in sebaceous tumors.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2007

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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