Faculty Advisor

Gaudette, Glenn R

Faculty Advisor

Pins, George

Abstract

Myocardial infarction afflicts millions of people. Infarcted heart tissue leaves patients with dysfunctional regions of cardiac muscle, which decreases cardiac function. While multiple treatments exist, most do not restore functional myocardium. The project goal was to develop a system to co-culture cardiac myocytes with mesenchymal stem cells to promote the expression of myocyte cell cycle markers, an indication of proliferation. We have demonstrated that this co-culture system is effective in culturing two discrete cell populations that can exchange media without cell-cell contact. This yields a pure population of cells that could be delivered to the heart to replace damaged myocardium. This design may also be used to co-culture any two cell types with adaptable spatial relationships.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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