Faculty Advisor

Gaudette, Glenn R.

Abstract

Myocardial infarction is characterized by the death of cardiomyocytes, the fundamental contractile units of the heart. Due to the cardiomyocyte's physiological importance, a more efficient and economical alternative to manual cell isolation is needed to obtain cells for in vitro studies. We designed a device that automates the teasing and mechanical agitation of heart tissue to obtain isolated cardiomyocytes. Through testing, our device met design goals for cell yield and viability while greatly reducing overall isolation duration and user interaction.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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