Faculty Advisor

Gaudette, Glenn R

Abstract

Myocardial infarction occurs when oxygen is depleted from cardiac muscle. Post myocardial infarction, the left ventricular wall is weakened due to the formation of scar tissue. As a result, a ventricular aneurysm may occur. This project aims to find a method of reinforcing the weakened tissue and restoring normal cardiovascular function. A scaffold for cardiac regeneration will provide the long term reinforcement necessary to prevent ventricular aneurysms and restore normal heart function. This paper proposes a method of restoring cardiac tissue through the use of a novel implantation method using an hMSC seeded scaffold that will temporarily support the area of weakened tissue and aid in the production of cardiac myocytes to re-establish a healthy ventricular wall.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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