Faculty Advisor

Adams, David S.

Abstract

Nearly 225 million cases of malaria were confirmed worldwide in 2009, causing 781,000 deaths. A majority of those deaths were among children in sub-Saharan Africa according to the World Health Organization. In this project the SIGLEC14/5 fusion gene was tested for its association with severe malaria, a complicated form of the disease, to help determine whether this copy number variant (CNV) plays a role in the genetic risk of severe malaria. Matched malarial cases and controls from Tanzania were genotyped using conventional PCR methods, then the data was compiled. The results indicate there is a possible association between this fusion gene and severe malaria. Further studies will need to be completed to confirm these assumptions.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2011

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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