Faculty Advisor

Rao, Reeta Prusty

Abstract

Aging blood vessels undergo physiological changes that result in reduced vasodilation, reduced responsiveness to stimuli, and increased stiffness. Specifically, older vasculature exhibits both increased ROS damage and reduced function of the vasoregulatory large-conductance Ca2+-activated K+ (BKCa) channel. We investigated if MitoTEMPO (a mitochondrial ROS scavenger) or rottlerin (a BKCa channel activator) can beneficially modulate vascular function in aged mouse aortas. Results showed that while both drugs significantly reduced vascular contraction in an age- dependent manner, they also reduced nitric oxide (NO) -mediated vasodilation. This negative trade-off suggests that these drugs may not be effective therapeutics for aging or diseased vessels.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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