Faculty Advisor

Emmert, Marion H

Center

WORC / Worcester Community Project Center

Abstract

One-step, non-directed C-H aminations of arenes has the potential to facilitate the synthesis of compounds with aromatic C-N bonds, which are important bulk and fine chemicals for the synthesis of biologically active molecules. Currently, these types of products are synthesized through sequential functional group interconversions. Our goal is to develop one-step, non-directed C-H amination reactions of arenes that are enabled by palladium catalysts and electrophilic amination reagents. The effect of palladium source, ligand, amination reagent, solvent, temperature and additives on the yield of amination reactions are investigated in detail.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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