Adams, David S.
Alcoholism is a complex disease with a number of components. Understanding ethanol preference, the tendency to choose ethanol over another drink, is the focus of this report. Genes whose activities constitute a basis for the ethanol preference phenotype have been previously reported. With the use of computational tools, high throughput microarray data was analyzed to identify transcription regulating relationships between subsets of specific genes of interest, including Carm1, Ube2m, Creb1, Crebbp, Stat3, Nfkbib and Atf2, among others. These findings confirm the importance of previously identified genes, and identify complex inter-connections between the regulations of many different pathways in the expression of the ethanol preference phenotype.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology