Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Ovarian cancer, when treated with platinum and taxanes, is frequently detected in later stages and often develops multi-drug resistant properties. Therefore, chemotherapy regiments can become ineffective, leaving clinicians with less efficacious therapies. Our hypothesis is that a nanotherapy approach, utilizing nanoemulsions (NE) to deliver a combination of drugs with synergistic mechanisms of action, will likely reduce the spread of ovarian cancer and deliver the combination with reduced systemic toxicity. Results suggest that combination NEs can be manufactured and show some promise to kill ovarian cancer cells more efficiently.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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