Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Over the counter (OTC) phytoestrogen supplements are marketed as alternative hormone replacement therapies but may increase the risk of hormone sensitive breast cancers. To begin to assess this risk, phytoestrogens were extracted from OTC supplements, separated using HPLC, and tested using an estrogen responsive breast epithelial cell line (MCF7). Results suggest lipid components of the OTC supplement Promensil have an antiproliferative effect on cultured breast cancer cells, though future research is recommended to outline the biochemical cause of this effect.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2016

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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