Roberts, Susan Celia
Paclitaxel is a taxane used to combat various forms of cancer. Formed in suspension cultures with other taxanes, purifying paclitaxel is difficult because most taxanes have a chemically similar structure. Molecularly imprinted polymers (MIPs) are artificial receptors that have the potential to alleviate this problem because they are engineered to selectively bind to target molecules. The goals of this project were to determine the optimum conditions for producing paclitaxel-specific MIPs and test their effectiveness in separating paclitaxel from a mixture of other taxanes. Based on various experiments, our group was able to produce MIPs that bound to 70% of paclitaxel in a 10 mg/L solution and proposed recommendations to produce more effective MIPs in the future.
Worcester Polytechnic Institute
Major Qualifying Project
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