Faculty Advisor

Roberts, Susan Celia

Abstract

Paclitaxel is a taxane used to combat various forms of cancer. Formed in suspension cultures with other taxanes, purifying paclitaxel is difficult because most taxanes have a chemically similar structure. Molecularly imprinted polymers (MIPs) are artificial receptors that have the potential to alleviate this problem because they are engineered to selectively bind to target molecules. The goals of this project were to determine the optimum conditions for producing paclitaxel-specific MIPs and test their effectiveness in separating paclitaxel from a mixture of other taxanes. Based on various experiments, our group was able to produce MIPs that bound to 70% of paclitaxel in a 10 mg/L solution and proposed recommendations to produce more effective MIPs in the future.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Chemical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemical Engineering

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