Faculty Advisor

Politz, Samuel M.

Abstract

Parasitic nematodes may cause biomedical and agricultural problems by avoiding host immune systems through changes in surface composition during infection, a process we call surface antigen switching. C. elegans is a free-living nematode serving as a model organism for antigen switching. srf-6 mutations change the developmental surface antigen display, and previous evidence suggests that srf-6 may be identical to the MAPKKK gene nsy-1. Complementation tests between srf-6 and nsy-1 mutants were conducted to support the hypothesis that srf-6 and nsy-1 affect the same genetic function.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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