Faculty Advisor

Dempski, Robert E.

Faculty Advisor

Politz, Samuel M.

Abstract

Parasitic nematodes may evade host immune systems by changing surface composition during infection. C. elegans is a free-living nematode with a conserved development and cuticle structure utilized as a parasitic model. srf-6 mutant worms fail to make surface antigen switches that occur facultatively in the wild type. The whole genome sequences of three srf-6 mutants were determined to identify the DNA sequence corresponding to srf-6. This project’s objective was to find and confirm srf-6 mutations in the genome sequence by re-sequencing the candidate gene in mutant DNA.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2014

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

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