Faculty Advisor

Skorinko, Jeanine LM

Faculty Advisor

Srinivasan, Jagan

Abstract

Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS) are common neurodegenerative disorders exhibiting male gender biases. The gender-related differences at both symptomatic and therapeutic levels are not understood. We developed C. elegans models for studying both disorders, and examined gender differences in symptom presentation using behavioral assays measuring locomotion and chemosensory abilities. Symptoms exhibiting gender bias had limited presentation in our models. Additionally, we investigated the efficacy of two potential treatments, caffeine and vanillin. We found that while treatment with caffeine had mixed results based on disease type, vanillin reduced neuronal deficits in both PD and ALS models.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Social Science and Policy Studies

Advisor Department

Biology and Biotechnology

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