Faculty Advisor

Reidinger, Amanda Zoe

Center

University of Massachusetts Medical Center

Abstract

PDT is an emerging cancer treatment that combines both light and a photosensitizing agent to produce reactive oxygen in cells. Although upconversion nanoparticles (UCNPs) are attracting much attention for their potential biological application, there are still several drawbacks that limit its general clinical use such as limited tissue penetration depth and sever overheating effect. Consequently, there has been extensive nanoparticle surface modification research into the design of improved alternative photosensitizers aimed at overcoming these drawbacks. Therefore, the goal of this project was to enhance the surface modification of UCNP to demonstrate high upconversion luminescence efficiency, as well as have hydrophilic surface characteristics that are compatible with biomolecule.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Project Center

University of Massachusetts Medical Center

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