Faculty Advisor

Reidinger, Amanda Zoe

Project Center

University of Massachusetts Medical Center


PDT is an emerging cancer treatment that combines both light and a photosensitizing agent to produce reactive oxygen in cells. Although upconversion nanoparticles (UCNPs) are attracting much attention for their potential biological application, there are still several drawbacks that limit its general clinical use such as limited tissue penetration depth and sever overheating effect. Consequently, there has been extensive nanoparticle surface modification research into the design of improved alternative photosensitizers aimed at overcoming these drawbacks. Therefore, the goal of this project was to enhance the surface modification of UCNP to demonstrate high upconversion luminescence efficiency, as well as have hydrophilic surface characteristics that are compatible with biomolecule.


Worcester Polytechnic Institute

Date Accepted

April 2015


Biomedical Engineering

Project Type

Major Qualifying Project



Advisor Department

Biomedical Engineering

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