Faculty Advisor

Coburn, Jeannine M

Abstract

Pediatric neuroblastoma patients have relatively high mortality rates and are commonly treated with systemic chemotherapy. Systemic chemotherapy causes adverse side effects that are especially harmful to the pediatric population. Localized, sustained release of chemotherapy drugs is a desirable alternative to systemic chemotherapy. There is a need for a drug delivery system to facilitate local delivery of chemotherapy drugs as well as to sustain the drug release over time. This project aims to design, fabricate, and validate a microparticle fabrication system for producing drug carrier microparticles for the delivery of chemotherapy drugs. The final drug-loaded microparticles were evaluated for induction of cytotoxicity in a neuroblastoma cell line.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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