Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Farny, Natalie

Abstract

Pesticides are ubiquitous in the environment and are found in human tissues. Using fluorescence microscopy, we examined the effects of the pesticides N-phosphonomethyl glycine (glyphosate) and 2,4-Dichlorophenoxyacetic acid (2,4-D) on formation of stress granules (SGs), cytoplasmic aggregates of silenced mRNPs formed under stress conditions. 2,4-D caused dose-dependent formation of SGs from 1 to 4 mM, while glyphosate caused no SG formation. Our work suggests some pesticides may affect cellular stress responses, and that further research is warranted.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2017

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

BIO

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