Phosphatidylserine (PS), one of the main components of the inner leaflet of the plasma membrane, plays an important role in various physiological processes including cell signaling. Its interaction with other lipids as well as bivalent cations has shown to lead to domain formation. For this project, PS monolayers at the air/water interface were studied in the presence and absence of calcium, where low concentrations of calcium lead to expansion of the monolayer and no domain formation while high concentrations of calcium lead to condensation and stability of the monolayer, as well as domain formation at low pressures. In addition, PS/PI(4,5)P2 monolayers at the air/water interface were studied in the presence and absence of calcium, where similar behavior was observed.
Worcester Polytechnic Institute
Major Qualifying Project
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.
Chemistry and Biochemistry