Faculty Advisor

Gericke, Arne

Abstract

Phosphatidylserine (PS), one of the main components of the inner leaflet of the plasma membrane, plays an important role in various physiological processes including cell signaling. Its interaction with other lipids as well as bivalent cations has shown to lead to domain formation. For this project, PS monolayers at the air/water interface were studied in the presence and absence of calcium, where low concentrations of calcium lead to expansion of the monolayer and no domain formation while high concentrations of calcium lead to condensation and stability of the monolayer, as well as domain formation at low pressures. In addition, PS/PI(4,5)P2 monolayers at the air/water interface were studied in the presence and absence of calcium, where similar behavior was observed.

Publisher

Worcester Polytechnic Institute

Date Accepted

March 2017

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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