Phosphatidylserine (PS), one of the main components of the inner leaflet of the plasma membrane, plays an important role in various physiological processes including cell signaling. Its interaction with other lipids as well as bivalent cations has shown to lead to domain formation. For this project, PS monolayers at the air/water interface were studied in the presence and absence of calcium, where low concentrations of calcium lead to expansion of the monolayer and no domain formation while high concentrations of calcium lead to condensation and stability of the monolayer, as well as domain formation at low pressures. In addition, PS/PI(4,5)P2 monolayers at the air/water interface were studied in the presence and absence of calcium, where similar behavior was observed.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Pinderi, Vanesa

Contributors

• Gericke, Arne

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-032417-025737

Advisor

• Gericke, Arne

Year

• 2017

Date created

• 2017-03-24

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright