Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Phytoestrogens are found in over the counter hormone replacement therapies and may react with the estrogen receptor in a manner similar to estrogen. A strain of MCF7 breast epithelial cells was cultured and assessed using an MTT cell proliferation assay. Assays were performed with combinations of IGF and estrogen to determine estrogen responsiveness. Although the strain of cells was not estrogen responsive, further testing on a different strain could determine how the phytoestrogens affect proliferation rates in comparison to estrogen.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2009

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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