Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Phytoestrogens are popular substances used in hormone replacement therapy due to their similar structure to estrogen and ability to interact like estrogens in the body. One particular phytoestrogen compound, genistein, has been observed to have an antiproliferative effect on breast cancer cells. The experiments investigated the effects of estrogen and genistein on the cells through MTS assays and PCNA immunoblots. The cell line demonstrated estrogen responsiveness through both assays, but results as to genistein's effect on the T47D breast epithelial cells were inconclusive.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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