Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Rulfs, Jill

Abstract

Phytoestrogens, plant produced hormones, are marketed to alleviate menopausal symptoms because studies indicate increased incidence of breast cancer in women undergoing estrogen Hormone Replacement Therapy. We studied the potential proliferative effects of phytoestrogens on the breast cancer cell line T47D-KBluc. HPLC isolated components of black cohosh, red clover, and grape seed extracts were assessed for proliferative effects using the MTT assay. Our results suggest that grape seed demonstrated the greatest proliferative effects.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2014

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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