Faculty Advisor

Adams, David S.

Abstract

Although cardiac natriuretic peptides (NPs) have well characterized roles as vasodilators, recent evidence indicates some NPs may also act to help regulate carbohydrate metabolism in brown fat. The purpose of this project was to examine whether ventricular (or brain-type) natriuretic peptide (B-type, BNP) affects glucose metabolism in tissues other than brown fat, especially in mouse skeletal muscle. Mice were fed a high-fat diet for 8 weeks, then glucose uptake in muscle was assayed using 2-[14C]-deoxyglucose-6-phosphate, and glycogen synthesis was monitored using 3H-glucose labeling into muscle glycogen. The data indicate that BNP treatment did not alter glucose metabolism in skeletal muscle, so perhaps BNP has no glucose metabolic effect on this particular peripheral tissue.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2014

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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