Porcine Circovirus Type 2 (PCV-2) is a single-stranded non-enveloped DNA virus belonging to the Circoviridae family that produces a novel viral protein, Viral Protein 3 (VP3) that is suspected of selectively killing transformed human cancer cells via an unknown mechanism. To understand this mechanism, PCV-2 VP3 is often compared to the Chicken Anemia Virus (CAV Apoptin), which has been shown to harbor killing capacity towards transformed cells in a p-53 independent manner. Here we investigate by Fluorescence Resonance Energy Transfer (FRET) PCV-2 VP3’s ability to multimerize as part of a mechanism-of-apoptosis.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry